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Weight gain can occur as a side effect of some beta blockers. The average weight gain is about 2. Weight gain is more likely with older beta blockers, such as atenolol Tenormin and metoprolol Lopressor, Toprol-XL. Newer beta blockers, such as carvedilol Coreg, don’t usually cause weight gain as a side effect. The good news is that weight gain tends to occur in the first few months after beginning the drug and then generally stops. The beta blockers associated with weight gain usually aren’t prescribed unless other medications haven’t worked. Or, they may be prescribed if you have a specific heart condition that’s helped by those medications. Beta blockers are used to treat a host of conditions, including high blood pressure, heart failure, migraines, glaucoma and anxiety. Doctors aren’t sure exactly why some beta blockers cause weight gain.