Very low calorie ketogenic diet VLCKD has been proposed as a promising option to achieve a significant weight loss in a short time period. We conducted a systematic review and meta-analysis to evaluate its efficacy and safety in patients with overweight and obesity. Four databases were searched on May Studies reporting data on body weight, body mass index BMI, waist circumference, body composition, blood pressure, HbA1c, lipids, and markers of liver and kidney function were selected. Discontinuation was also assessed. Twelve studies were included. The present review supports the use of VLCKD as an effective strategy for the management of overweight and obesity.
Metrics details. Very low-calorie ketogenic diets VLCKD is increasingly establishing as a successful nutritional pattern to manage obesity; this is due to rapid weight loss that gives rise to a positive psychological cycle which in turn increases the compliance to diet. Another important key point of VLCKD is the ability to preserve fatty free mass which is known to play a role of paramount importance in glucose metabolism. Therefore, we will provide a useful guide to be used by nutrition experts taking care of subjects with obesity. In particular, we will report recommendations on the correct use of this therapeutic approach for weight loss and management of side effects. Growing evidence reported that obesity is reaching epidemic proportions. Obesity could be defined as the silent killer; in fact, it significantly increases the risk of contracting diseases, such as: arterial hypertension, dyslipidemia, type 2 diabetes mellitus T2DM, coronary heart disease, cerebral vasculopathy, gallbladder lithiasis, arthropathy, ovarian polycytosis, sleep apnea syndrome, and some neoplasms [ 2, 3 ]. In order to reach weight loss, one of the most important challenge in the management of obesity is reducing energy intake and increasing energy output. Although several strategies has been developed to reach this goal, this disorder is increasing in prevalence.
Background: Low-carbohydrate diets remain popular despite a paucity of scientific evidence on their effectiveness. Objective: To compare the effects of a low-carbohydrate, ketogenic diet program with those of a low-fat, low-cholesterol, reduced-calorie diet. Design: Randomized, controlled trial. Setting: Outpatient research clinic. Participants: overweight, hyperlipidemic volunteers from the community. Measurements: Body weight, body composition, fasting serum lipid levels, and tolerability. At 24 weeks, weight loss was greater in the low-carbohydrate diet group than in the low-fat diet group mean change, Patients in both groups lost substantially more fat mass change, Compared with recipients of the low-fat diet, recipients of the low-carbohydrate diet had greater decreases in serum triglyceride levels change, Changes in low-density lipoprotein cholesterol level did not differ statistically 0.