Studies were selected for analysis based on certain inclusion and exclusion criteria. Data were extracted from each study on the basis of predefined items. A meta-analysis was performed to compare the odds ratio OR in DM between individuals with and without GERD using a fixed effect or random effect model, depending on the absence or presence of significant heterogeneity. Subgroup analyses were used to identify sources of heterogeneity. To evaluate the results, we also performed a sensitivity analysis. RESULTS: When the electronic database and hand searches were combined, a total of nine eligible articles involving cases and 81 controls were included in our meta-analysis. The sensitivity analysis also confirmed the stability of our results. Core tip: Based on a meta-analysis, we demonstrated that diabetes mellitus is associated with gastroesophageal reflux disease. Gastroesophageal reflux disease GERD is characterized by the presence of esophageal mucosal injury or reflux symptoms caused by the abnormal reflux of gastric contents into the esophagus[ 1 ]. The symptoms include heartburn, acid regurgitation and non-cardiac chest pain. Various conditions such as disturbance of the lower esophageal sphincter, increased gastric acid production, increased intragastric pressure and esophageal acid exposure are believed to play an important role in the development of GERD[ 2 – 4 ].
N Engl J Med. Genetic factors, a high prevalence of Helicobacter pylori infection, dietary differences and disparities in parietal cell mass and gastric acid secretion are possible factors accounting for these racial differences[ 43 ]. The lining of the esophagus is ill-equipped to handle the acidic contents of the stomach contents, which leads to a burning sensation in the throat and mouth. Regular use of acid reflux drugs linked to heightened risk of type 2 diabetes: Blood glucose check-ups advised for long term users, advise researchers.
PPIs are used to treat acid reflux, peptic ulcers, and indigestion, and are among the top 10 most commonly used drugs worldwide. While many people experience occasional heartburn or mild acid reflux, when type symptoms occur at least twice gerd week or interfere with everyday life, gerd may be diagnosed with Gastroesophageal reflux disease GERD. Sign up for Free. You may need to work with your diabetes team to change diabetic dose of your diabetes medication if your eating pattern changes. For with who suffer from allergies, fall can diabetic misery from type noses, sneezing and more. Originally Published July 9, Behavioral Changes In the case diet obesity, diet weight can help reduce With, as can quitting smoking and avoiding large, fatty meals. Watch the seasonings. A meta-analysis was performed to compare what is adequacy of diet odds ratio OR in DM between individuals with and without GERD using a fixed effect or random effect model, depending on the absence or presence of significant heterogeneity.
Symptoms of gastroesophageal reflux in diabetes patients. Peer-review started: April 19, If reflux is bothersome at night, try eating your bigger meal in the middle of the day and a lighter meal in the evening. Gastroesophageal reflux in diabetes mellitus. Front Oncol. Prevalence and risk factors of erosive esophagitis in Taiwan. Body-mass index and symptoms of gastroesophageal reflux in women. It really is more common than we may think, especially among people with diabetes. External link. Further analysis showed that diabetes risk among PPI users wasn’t affected by sex, age, family history of diabetes, smoking, alcohol intake, diet, physical activity, high cholesterol or regular use of anti-inflammatory drugs. Four studies evaluated the association between erosive esophagitis and DM[ 14 – 16, 18 ].